Free Patient Resource
A plain-English guide to help you decide whether to explore Scrambler Therapy for chronic or neuropathic pain — what it actually is, the only two authentic devices, the questions to ask before you book, and how to find a qualified provider.
01 — Introduction
Scrambler Therapy® — also known as Calmare® Therapy — is a non-invasive, drug-free treatment for chronic and neuropathic pain. It was invented by Professor Giuseppe Marino in Italy and uses small surface electrodes (similar to EKG pads) placed on the skin near the area of pain.
Instead of blocking or numbing pain signals, the device sends carefully shaped electrical signals through the same nerves that are transmitting pain. The brain receives these new signals as "non-pain" information. Over a series of sessions, the goal is to retrain the nervous system so that it stops interpreting those signals as pain.
A typical course is roughly 10 consecutive weekday sessions, each about 30–45 minutes. Many patients report meaningful relief during or shortly after treatment, though results vary by condition, provider, and protocol.
02 — The technology
There are only two genuine sources of Scrambler Therapy technology in the United States. Both deliver the same underlying technology originally developed by Professor Marino. The outer casing and controls look a little different, but the core waveform is the same. If a clinic is using anything else — a TENS unit, an "advanced" muscle stimulator, or an unbranded knock-off — it is not genuine Scrambler Therapy.

Calmare® MC-5A
Distributed in the U.S. by Calmare Therapeutics.

Scrambler Therapy™ ST-5A
Distributed by Delta Research & Development (Italy).
Because the two distributors operate independently, each runs its own training and there is no universal standard of care or accreditation body governing how providers are taught. That means the device matters, the protocol matters, and — maybe most of all — the provider matters.
03 — Before you book
Because there is no single curriculum or governing body, two clinics legitimately offering "Scrambler Therapy" can deliver very different experiences. These questions will quickly tell you how committed and experienced a provider really is:
The depth and confidence of the answers tells you a great deal about the level of expertise you can expect.
04 — Safety
Scrambler Therapy is generally considered very safe and well-tolerated, but it is not appropriate for everyone. Talk with your physician and the provider before starting treatment if any of the following apply:
A qualified provider will screen you for these and other factors before your first session. If they don't, that itself is a warning sign.
05 — Next step
Because experience and protocol vary so much from clinic to clinic, finding the right provider is the single most important decision you'll make. We've built a free, searchable map of Scrambler Therapy providers to make that easier.
When you contact a provider, bring the questions from section 3 with you. A great provider will welcome them.
06 — Important
This guide is for general informational purposes only. This resource is not intended to diagnose, treat, cure, or prevent any disease or medical condition, and is not a substitute for — or alternative to — information and care from a licensed healthcare professional.
Please consult your healthcare provider about your specific condition, potential interactions, and any possible complications before starting Scrambler Therapy or any other treatment.